期刊
RESEARCH IN VETERINARY SCIENCE
卷 89, 期 3, 页码 445-450出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.rvsc.2010.04.013
关键词
ATP synthase; Bovine skeletal muscles; Cytochrome-c oxidase; Insulin; Myogenesis; Pregnancy
资金
- Ministry of Science and Higher Education in Poland [N401 033 32/0759, 117/E-385/SPB/COST/P-06/DWM]
The aim of this study was to investigate the evolution of the abundance of cytochrome oxidase c subunit IV (NCOIV) and beta subunit of ATP synthase (beta-ATP) during the last third of gestation in bovine skeletal muscles. Semitendinosus, longissimus thoracis and rectus abdominis muscles were chosen for the immunoblotting of the respective protein levels. Muscle and blood samples from bovine fetuses of randomly selected breeds were collected at 180, 210, and 260 days post-conception (dpc). The muscle tissue expressions of NCOIV, beta-ATP were compared to blood glucose and insulin. At 260 dpc, protein levels of NCOIV raised in skeletal muscles. Additionally, beta-ATP in semitendinosus and longissimus thoracis were elevated and paralleled by higher concentrations of blood serum insulin. It corroborates our previous observations indicating that accelerated metabolic differentiation of bovine skeletal muscles is associated with elevated blood insulin and occurs during the last trimester of gestation. Our observations point to the connection between insulin-sensitivity and the molecular mechanisms of mitochondrial contribution to ontogenesis of skeletal muscles. (C) 2010 Elsevier Ltd. All rights reserved.
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