Acute Antioxidant Supplementation Improves Endurance Performance in Trained Athletes

This study examined the acute effects of a single dose of an antioxidant (AO; Lactaway (R) containing pycnogenol) on time to fatigue (TTF). Nine trained cyclists [mean +/- SD age 35 +/- 10 yrs; body mass 71.6 +/- 10.2 kg; VO(2)peak 63 +/- 11 ml/kg/min] performed on two separate occasions a continuous protocol of 5 min at 50% of peak power output (PPO), 8 min at 70% of PPO, and then cycled to fatigue at 95% PPO. Four hours prior to the exercise protocol, the subjects consumed the supplement or a placebo (counterbalanced, double blind protocol). Cyclists, on average, rode for 80 s more in the Lactaway trial than they did in the placebo trial. There was considerable evidence (chances >= 94.5%) for substantial positive treatment effects for TTF and the other performance-related variables (excluding [BLa] at 95% PPO). Other studies are necessary to confirm these results and identify the mechanisms underlying the observed effects.