期刊
JOURNAL OF DIABETES INVESTIGATION
卷 6, 期 5, 页码 587-590出版社
WILEY-BLACKWELL
DOI: 10.1111/jdi.12330
关键词
Ketoacidosis; Low-carbohydrate diet; Sodium-glucose cotransporter2 inhibitor
We present a case of a 32-year-old diabetic woman with Prader-Willi syndrome who developed severe ketoacidosis caused by a sodium-glucose cotransporter2 (SGLT2) inhibitor, a novel class of antihyperglycemic agents, during a strict low-carbohydrate diet. At admission, a serum glucose level of 191mg/dL was relatively low, though laboratory evaluations showed severe ketoacidosis. This is the first report of ketoacidosis caused by a SGLT2 inhibitor. It is necessary to not only pay attention when using a SGLT2 inhibitor in patients following a low-carbohydrate diet, but also to start a low-carbohydrate diet in patients treated with a SGLT2 inhibitor because of a high risk for developing ketoacidosis.
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