期刊
RESEARCH IN MICROBIOLOGY
卷 164, 期 10, 页码 998-1008出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.resmic.2013.10.003
关键词
Bacillus subtilis; WalR; sigI; mreBH; lytE; Heat stress
类别
资金
- National Science Council [NSC 101-2311-B-010-002]
- Ministry of Education of the Republic of China
The actin homolog MreBH governs cell morphogenesis of Bacillus subtilis through localization of the cell wall hydrolase LytE. The alternative sigma factor SigI of B. subtilis coordinately regulates transcription of mreBH and lytE. Transcription of sigI, mreBH and lytE is heat-inducible. The essential response regulator WalR (YycF) plays a key role in coordinating cell wall metabolism with cell proliferation. We now demonstrate that mreBH is a new member of the WalR regulon. We also found that WalR can positively and directly regulate sigI transcription under heat stress through a binding site located upstream of the sigma(I) promoter of sigI. In addition, we found that a WalR binding site located upstream of the SigI binding site in the regulatory region of lytE is important for lytE expression under heat stress. Moreover, we found that walR is a new member of the heat shock stimulon of B. subtilis. WalR appears to coordinately and positively regulate transcription of sigI,mreBH and lytE under heat stress. Finally, our work shows for the first time that WalR can stimulate activities of sigma(I) promoters under heat stress. (C) 2013 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
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