期刊
RESEARCH IN MICROBIOLOGY
卷 162, 期 6, 页码 607-618出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.resmic.2011.03.003
关键词
Naegleria; Genome; Evolution; Ploidy; Mitosis; Nucleolus
类别
资金
- NIAID NIH HHS [R01 AI077571] Funding Source: Medline
Naegleria gruberi, a free-living protist, has long been treasured as a model for basal body and flagellar assembly due to its ability to differentiate from crawling amoebae into swimming flagellates. The full genome sequence of Naegleria gruberi has recently been used to estimate gene families ancestral to all eukaryotes and to identify novel aspects of Naegleria biology, including likely facultative anaerobic metabolism, extensive signaling cascades, and evidence for sexuality. Distinctive features of the Naegleria genome and nuclear biology provide unique perspectives for comparative cell biology, including cell division, RNA processing and nucleolar assembly. We highlight here exciting new and novel aspects of Naegleria biology identified through genomic analysis. (c) 2011 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
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