期刊
RESEARCH IN MICROBIOLOGY
卷 161, 期 2, 页码 153-157出版社
ELSEVIER
DOI: 10.1016/j.resmic.2009.12.001
关键词
PmrAB system; Iron; Acidic pH; Polymyxin B; Survival
类别
资金
- United States Department of Agriculture (USDA)
- United States Department of Agriculture (USDA) - National Institute of Food and Agriculture (NIFA) [Illu-802-317]
- Agricultural Experiment Station of Illinois
The PmrAB system is a two-component regulatory system that responds to extracellular iron and acidic pH. The role of the PmrAB system in Erwinia amylovora remains unknown so far. Our results showed that the pmrAB mutants were more resistant to strong acidic conditions than the wild type (WT) strain. The survival rate of the pmrAB mutants was much higher than that of WT when treated with polymyxin B. However, pmrAB mutants were more sensitive to extracellular iron than WT strain. These results demonstrated that the PmrAB system in E. amylovora renders the pathogen more susceptible to polymyxin B and acidic pH, but more resistance to excess iron. (C) 2009 Elsevier Masson SAS. All rights reserved.
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