期刊
RESEARCH IN MICROBIOLOGY
卷 160, 期 5, 页码 353-357出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.resmic.2009.04.007
关键词
Biofilms; Nitrofurans; NO; NO donors; Pseudomonas aeruginosa; Burkholderia cenocepacia
类别
资金
- Russian Foundation [09-04-00422]
Antibacterial drugs in the nitrofuran series, such as nitrofurazone, furazidin, nitrofurantoin and nifuroxazide, as well as the nitric oxide generators sodium nitroprusside and isosorbide mononitrate in concentrations that do not suppress bacterial growth, were shown to increase the capacity of pathogenic bacteria Pseudomonas aeruginosa PAO1 and Burkholderia cenocepacia 370 to form biofilms. At 25-100 mu g/ml, nitrofurans 2-2.5-fold enhanced biofilm formation of P. aeruginosa PAO1, and NO donors 3-6-fold. For B. cenocepacia 370, the enhancement was 2-5-fold (nitrofurans) and 4.5-fold (sodium nitroprusside), respectively. (C) 2009 Elsevier Masson SAS. All rights reserved.
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