期刊
REPRODUCTIVE TOXICOLOGY
卷 47, 期 -, 页码 70-76出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.reprotox.2014.06.002
关键词
Environment; Exposure; Testosterone; Puberty; Tanner stage; Bisphenol A
资金
- National Institute of Environmental Health Sciences, National Institutes of Health [P20 ES018171, P01ES022844, P30ES017885]
- US Environmental Protection Agency [RD83480001]
Phthalates and BPA are known endocrine disruptors and exposure in pregnant mothers and children is ubiquitous. We explored the relationship of prenatal and childhood exposures with pubertal onset and sex hormones in boys (ages 8-14). Phthalate metabolites and BPA were measured in maternal 3rd trimester or childhood urine. Sex hormones DHEAS, estradiol, inhibin B, SHBG, and total testosterone were measured in serum. Adrenarche and puberty were assessed by pediatrician. Prenatal exposure to some phthalates was associated with decreased DHEAS and inhibin B levels, and with increased SHBG. Prenatal exposure to most phthalates and BPA was associated with greatly reduced odds of adrenarche (odds ratios [OR] = 0.12-0.65) and slightly reduced odds of puberty (OR=0.50-0.98). Childhood exposure was not associated with adrenarche or puberty, but some phthalates and BPA were associated with increased SHBG levels and decreased total and free testosterone levels. (C) 2014 Elsevier Inc. All rights reserved.
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