期刊
REPRODUCTIVE TOXICOLOGY
卷 47, 期 -, 页码 81-88出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.reprotox.2014.06.005
关键词
Zearalenone; Multipregnancy; Multigeneration; Vaginal opening; Embryo implantation; Litter size; Female reproduction
资金
- Office of the Vice President for Research, Interdisciplinary Toxicology Program
- Department of Physiology and Pharmacology at the University of Georgia
- National Institutes of Health [NIH R15HD066301, NIH R01HD065939]
- ORWH
- NICHD
This study investigated potential cumulative effects of multiple pregnancy and multigenerational exposure to dietary ZEA (0, 0.8, 4, or 20 ppm) on female puberty and reproduction in C57BL/6J mice. Multiple pregnancies did not significantly affect litter size or offspring puberty. Significant effects were observed in 20 ppm ZEA-treated females: advanced puberty onset in F0, F1, and F2 generations; decreased implantation rate, pregnancy rate, and litter size, and increased pregnancy gap and gestation period in F1 and F2 generations; and reduced fertility index in F2 generation. F3 females from 0 and 20 ppm groups were split into 0 or 20 ppm ZEA diets at weaning, with advanced puberty onset seen in 0-20 and 20-20 groups and decreased implantation rate observed in 20-20 group. In summary, 20 ppm dietary ZEA advanced puberty onset without obvious cumulative effect and impaired fertility with multigenerational cumulative effect, which could be partially alleviated upon exposure cessation. (C) 2014 Elsevier Inc. All rights reserved.
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