期刊
REPRODUCTIVE TOXICOLOGY
卷 42, 期 -, 页码 256-268出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.reprotox.2013.07.017
关键词
Metabolic syndrome; Adipocytes; Food intake; Glucose tolerance; Endocrine disruption
资金
- NIEHS [ES018764, ES021394]
Exposure to bisphenol A (BPA) is implicated in many aspects of metabolic disease in humans and experimental animals. We fed pregnant CD-1 mice BPA at doses ranging from 5 to 50,000 mu g/kg/day, spanning 10-fold below the reference dose to 10-fold above the currently predicted no adverse effect level (NOAEL). At BPA doses below the NOAEL that resulted in average unconjugated BPA between 2 and 200 pg/ml in fetal serum (AUC(o-24h)), we observed significant effects in adult male offspring: an age-related change in food intake, an increase in body weight and liver weight, abdominal adipocyte mass, number and volume, and in serum leptin and insulin, but a decrease in serum adiponectin and in glucose tolerance. For most of these outcomes non-monotonic dose-response relationships were observed; the highest BPA dose did not produce a significant effect for any outcome. A 0.1-mu.g/kg/day dose of DES resulted in some but not all low-dose BPA outcomes. (C) 2013 Elsevier Inc. All rights reserved.
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