期刊
REPRODUCTIVE TOXICOLOGY
卷 33, 期 4, 页码 513-530出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.reprotox.2011.08.004
关键词
Perfluorobutyrate (PFBA); Perfluorooctanoate (PFOA); Repeat-dose toxicity; Rats
资金
- U.S. Environmental Protection Agency
Sequential 28-day and 90-day oral toxicity studies were performed in male and female rats with ammonium perfluorobutyrate (NH(4)(+)PFBA) at doses up to 150 and 30 mg/kg-d, respectively. Ammonium perfluorooctanoate was used as a comparator at a dose of 30 mg/kg-d in the 28-day study. Female rats were unaffected by NH(4)(+)PFBA. Effects in males included: increased liver weight, slight to minimal hepatocellular hypertrophy: decreased serum total cholesterol: and reduced serum thyroxin with no change in serum thyrotropin. During recovery, liver weight, histological, and cholesterol effects were resolved. Results of RT-qPCR were consistent with increased transcriptional expression of the xenosensor nuclear receptors PPAR alpha and CAR as well as the thyroid receptor, and decreased expression of Cyp1A1 (Ah receptor-regulated). No observable adverse effect levels (NOAELs) were 6 and >150 mg/kg-d for male and female rats in the 28-day study and 6 and >30 mg/kg-d in the 90-dat study, respectively. (C) 2011 Elsevier Inc. All rights reserved.
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