期刊
REPRODUCTIVE TOXICOLOGY
卷 33, 期 2, 页码 198-204出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.reprotox.2011.04.005
关键词
Gonadotropin-releasing-hormone (GnRH); Aromatase B (cyp19a1b); Zebrafish (Danio rerio); 17 alpha-Ethinylestradiol; Nonylphenol; Endocrine disruption
资金
- French Ministry of Ecology and Sustainable Development [189_09 DRC01]
- French National Research Agency
There is growing evidence that neuroendocrine circuits controlling development and reproduction are targeted by EDCs. We have previously demonstrated that low concentrations of 17 alpha-ethinylestradiol (EE2) disrupt the development of forebrain GnRH neurons during zebrafish development. The objectives of the present study were to determine whether the weak estrogenic compound, nonylphenol (NP), could elicit similar effects to EE2 and to what extent the estrogen receptors are involved in mediating these effects. Using immunohistochemistry, we confirmed that EE2 exposure induces an increase in the number of GnRH-ir neurons and we demonstrated that NP is able to produce similar effects in a concentration-dependent manner. The effects of both NP and EE2 were shown to be blocked by the estrogen receptors (ERs) antagonist ICI 182-780, demonstrating the involvement of functional ERs in mediating their effects. Altogether, these results highlight the need to consider neuroendocrine networks as critical endpoints in the field of endocrine disruption. (C) 2011 Elsevier Inc. All rights reserved.
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