期刊
REPRODUCTIVE TOXICOLOGY
卷 32, 期 4, 页码 434-441出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.reprotox.2011.08.010
关键词
Bisphenol A; Embryo implantation; Embryo transport; Preimplantation embryo development; Uterine receptivity; Progesterone receptor
资金
- Office of the Vice President for Research
- Interdisciplinary Toxicology Program
- Department of Physiology and Pharmacology at University of Georgia
- NIH [R15HD066301]
To investigate the effects of bisphenol A (BPA) on embryo and uterine factors in embryo implantation, timed pregnant C57BL6 females were treated subcutaneously with 0, 0.025, 0.5, 10, 40, and 100 mg/kg/day BPA from gestation days 0.5-3.5. In 100 mg/kg/day BPA-treated females, no implantation sites were detected on day 4.5 but retention of embryos in the oviduct and delayed embryo development were detected on day 3.5. When untreated healthy embryos were transferred to pseudopregnant females treated with 100 mg/kg/day BPA, no implantation sites were detected on day 4.5. In 40 mg/kg/day BPA-treated females, delayed implantation and increased perinatal lethality of their offspring were observed. Implantation seemed normal in the rest BPA-treated groups or the female offspring from 40 mg/kg/day BPA-treated group. These data demonstrate the adverse effects of high doses of BPA on processes critical for embryo implantation: embryo transport, preimplantation embryo development, and establishment of uterine receptivity. (C) 2011 Elsevier Inc. All rights reserved.
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