期刊
REPRODUCTIVE TOXICOLOGY
卷 31, 期 4, 页码 546-550出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.reprotox.2011.02.005
关键词
PBDE; PCB; p-p ' DDE; Sperm count; Thyroid hormones
资金
- University of Sherbrooke
Background: Polybrominated diphenyl ethers are known to be endocrine disruptors and may affect male reproduction. This exploratory study investigated semen parameters and serum thyroid hormones in relation to serum PBDE, PCBs and p-p' DDE in adult men. Methods: Fifty-two men were recruited in a fertility clinic. Semen counts were done for each participant. Serum thyroid hormone and PBDE, PCB and p-p' DDE levels were measured. Sociodemographic questionnaire were administered to each participant and all medical data were obtained from medical record. Results: Semen mobility was negatively related to BDE-47, BDE-100 and Sigma BDE. No relations were observed with other semen parameters. Thyroxin levels were negatively associated to serum BDE-47, BDE-99, Sigma BDE and p-p' DDE and positively related to Sigma PCB. No relations were observed between T3, TSH and any of the chemicals measured. Conclusion: These findings increased the evidence that PBDE may interfere with semen quality and thyroid status in general population. (C) 2011 Elsevier Inc. All rights reserved.
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