期刊
REPRODUCTIVE TOXICOLOGY
卷 29, 期 3, 页码 323-331出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.reprotox.2009.12.006
关键词
Atrazine; Testis; Adrenal; 3 beta-HSD; Androgen receptor; Endocrine disruptor
资金
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico, CNPq/Brazi [578429/2008-0]
- Pro-Reitoria de Pesquisa da Universidade Federal de Minas Gerais-PRPq/UFMG
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior, CAPES
- Fundacao de Amparo a Pesquisa do Estado de Minas Gerais-FAPEMIG/Brazil
Atrazine is an herbicide considered as a potent endocrine disruptor, causing adverse effects on both gender of mammalian and non-mammalian species. Despite the known adverse effects of Atrazine, little is known about its action on male genital system, especially in adults. We evaluated the effects of Atrazine (50 mg/kg, 200 mg/kg and 300 mg/kg) in the 3 beta-hydroxysteroid dehydrogenase (3 beta-HSD) expression, plasmatic and testicular estrogen and testosterone levels. androgen receptor expression and morphological changes in adult rat testes. Atrazine at doses higher than 50 mg/kg resulted in decreased body weight, increased adrenal weight and transient increase in testis weight, followed by testis atrophy. A reduction in testosterone but increase in estradiol levels was observed. We showed for the first time that testicular 3 beta-HSD protein was decreased, whereas in the adrenal it was unchanged. The results suggest that 3 beta-HSD inhibition may represent an alternative mechanism through which Atrazine affects the testicular androgenesis. leading to changes in spermatogenesis. (C) 2010 Elsevier Inc. All rights reserved.
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