期刊
REPRODUCTIVE TOXICOLOGY
卷 30, 期 1, 页码 131-137出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.reprotox.2010.02.007
关键词
Bisphenol A; Fetal exposure; Placental transport; In vitro; Endocrine disruptor; Trophoblasts; Dermal permeation
资金
- EU [LSHB-CT-2004-03257, FOOD-CT-2005-016320]
- Danish Environmental Protection Agency
Bisphenol A (BPA), an estrogen-like chemical, leaches from consumer products potentially causing human exposure. To examine the effects of BPA exposure during pregnancy, we performed studies using the BeWo trophoblast cell line, placental explant cultures, placental perfusions and skin diffusion models, all of human origin. Results showed BPA cytotoxicity in BeWo cells with an apparent EC50 at 100-125 mu M. BPA exposure significantly increased beta-hCG secretion and caspase-3 expression in placental explants at an environmentally relevant concentration of 1 nM. In the transport studies, a rapid transfer of BPA was observed across the term placentae and the BeWo cell monolayer. Further, transdermal transport of BPA was observed. These results indicate that fetal BPA exposure through placental exchange occurs with potential adverse implications for placental and fetal development. This battery of test systems within the realm of human implantation and fetal development represents important elements in risk assessment of reproductive toxicity. (C) 2010 Elsevier Inc. All rights reserved.
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