期刊
REPRODUCTIVE SCIENCES
卷 20, 期 10, 页码 1215-1223出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/1933719113483008
关键词
endometriosis; Wenshen Xiaozheng Tang; inflammation; invasion
资金
- Open Project Program of Traditional Chinese Medicine Department of Nanjing University of Chinese Medicine, Nanjing, China [YS2012ZYX315]
- Science and Technology Project, Jiangsu Province Bureau of Traditional Chinese Medicine [LZ11057]
- Scientific Research Starting Foundation for Introduced Talents, Jiangsu Province Academy of Traditional Chinese Medicine [RC1107]
The objective of this study is to investigate the effect of Wenshen Xiaozheng Tang (WXT) on the development of endometriosis in a rat model. Sprague-Dawley rats in which endometriotic implants were induced were divided randomly into 3 groups. The rats in the low-dose and high-dose WXT groups were administered WXT 8.57 and 17.14 g/kg/d, respectively. The rats in the control groups received an equal volume of dissolvent, as did the sham-operated rats. After treatment for 4 weeks, WXT significantly decreased the mean lesion size as well as the peritoneal fluid and serum levels of tumor necrosis factor and interleukin 1. Cyclooxygenase-2, matrix metalloproteinase 9, plasminogen activator inhibitor 1, and intercellular adhesion molecule 1 messenger RNA (mRNA) levels were downregulated, and the mRNA expression of tissue inhibitor of metalloproteinase 1 was upregulated in the endometriotic lesions of WXT versus control group. Our data suggested that WXT may suppress the development of endometriosis by inhibiting the production of proinflammatory cytokines and regulating the expression of invasion-related genes in the endometriotic lesions.
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