期刊
REPRODUCTIVE SCIENCES
卷 19, 期 1, 页码 6-13出版社
SPRINGER HEIDELBERG
DOI: 10.1177/1933719111424446
关键词
prematurity; preterm labor; epigenetics; genetics; DNA
资金
- NIMH NIH HHS [K01 MH085806] Funding Source: Medline
- NATIONAL INSTITUTE OF MENTAL HEALTH [K01MH085806] Funding Source: NIH RePORTER
Spontaneous preterm birth (PTB; birth prior to 37 weeks of gestation) is a complex phenotype with multiple risk factors that complicate our understanding of its etiology. A number of recent studies have supported the hypothesis that epigenetic modifications such as DNA methylation induced by pregnancy-related risk factors may influence the risk of PTB or result in changes that predispose a neonate to adult-onset diseases. The critical role of timing of gene expression in the etiology of PTB makes it a highly relevant disorder in which to examine the potential role of epigenetic changes. Because changes in DNA methylation patterns can result in long-term consequences, it is of critical interest to identify the epigenetic patterns associated with adverse pregnancy outcomes. This review examines the potential role of DNA methylation as a risk factor for PTB and discusses several issues and limitations that should be considered when planning DNA methylation studies.
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