期刊
REPRODUCTIVE SCIENCES
卷 18, 期 5, 页码 418-425出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/1933719111398148
关键词
multifactorial; azoospermia; epigenetics; MicroRNA; HPG axis
Infertility is a major reproductive health problem affecting 10% to 15% of couples, with approximately equal contributions. Spermatogenesis is a dynamic and multistep process of male germ cell proliferation and differentiation by which spermatozoa are produced from primordial germ cells. The causes of spermatogenic defects in infertile men are multifactorial and many environmental, nutritional, behavioral and genetic factors affect male infertility. In most of the infertile cases, the underlying mechanisms remain obscure. Genomics and proteomics offer new tools for better understanding the genetics of male infertility. The current review provides insights into the plausible chromosomal, genetic and epigenetic alterations, which may result into infertile phenotype.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据