期刊
REPRODUCTIVE SCIENCES
卷 17, 期 10, 页码 931-940出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/1933719110374239
关键词
curcumin; apoptosis; angiogenesis; VEGF; ovarian cancer; antioxidants
资金
- Caldwell Family Foundation
- Vesa W. and William J. Hardman, Jr. Charitable Foundation Inc
Curcumin, a component of turmeric, has been reported to exhibit potential antitumor activities. This study assessed the effects of a novel synthetic curcumin analog, EF24, on proliferation, apoptosis, and vascular endothelial growth factor (VEGF) regulation in platinum-sensitive (IGROV1) and platinum-resistant (SK-OV-3) human ovarian cancer cells. EF24 time-and dose-dependently suppressed the growth of both cell lines and synergized with cisplatin to induce apoptosis. Although treatment with EF24 had no significant effect on VEGF messenger RNA (mRNA) expression, VEGF protein secretion into conditioned media was dose-dependently reduced with EF24 demonstrating similar to 8-fold greater potency than curcumin (P < .05). EF24 significantly inhibited hydrogen peroxide (H2O2)-induced VEGF expression, as did the phenolic antioxidant tert-butylhydroquinone (t-BHQ). EF24 upregulated cellular antioxidant responses as observed by the suppression of reactive oxygen species (ROS) generation and activation of antioxidant response element (ARE)-dependent gene transcription. Given its high potency, EF24 is an excellent lead candidate for further development as an adjuvant therapeutic agent in preclinical models of ovarian cancer.
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