期刊
REPRODUCTIVE SCIENCES
卷 15, 期 9, 页码 866-877出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/1933719108322425
关键词
Placenta; gestational age; microarray; Wnt pathway; xenobiotic transporters; metabolizing enzymes
资金
- NICHD [HD47892, P50 HD44404]
- NIEHS [P30ES07033]
- Center for Ecogenetics and Environmental Health [P30ES07033]
- Astellas Foundation
We used the whole-genome approach to identify major functional categories of genes whose expression depends on gestational age. Using microarray analysis, we compared gene expression profiles in the villous tissues of first (45-59 days) and second trimester (190-115 days) placentae with C-section term placentae. We found that in first trimester placentae, genes related to cell cycle DNA, amino acids, and carbohydrate metabolism were significantly overrepresented, while genes related to signal transduction were underrespresented. Among genes involved in organism defense, we identified genes involved in chemical response, metabolism, and transport. Analysis of signal transduction pathways suggested, and subsequently confirmed independently, that the Wnt pathway was changed with gestational age leading to inhibition of beta-catenin protein expression. Our study will serve as a reference database to gain insight into the regulation of gene expression in the developing placentae and to compare with gene expression in placentae from complicated pregnancies.
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