期刊
REPRODUCTIVE SCIENCES
卷 15, 期 6, 页码 613-620出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/1933719108317299
关键词
neonatal hypoxia-ischemia; neural stem/progenitor cells; chondroitin sulfate; chondroitinase ABC
资金
- Grants-in-Aid for Scientific Research [20591240] Funding Source: KAKEN
Perinatal hypoxia-ischemia (HI) remains a critical issue. Cell transplantation therapy could be a potent treatment for many neurodegenerative diseases, but limited works on this hind of therapy have been reported for perinatal HI. In this study, the therapeutic effect of transplantation with neural stem/progenitor cells (NSPCs) and chondrotinase ABC (ChABC) in a neonatal HI rat model is evaluated. Histological studies showed that the unaffected area of the brain in animals treated with NSPCs together with ChABC was significantly larger than that in the animals treated with vehicle or NSPCs alone. The wet weight of the brain. that received the combined treatment was also significantly higher than those of the vehicle and their individual treatments. These results indicate that intracerebroventricular injection of NSPCs with ChABC reduces brain injury in a rat neonatal HI model.
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