期刊
REPRODUCTIVE BIOMEDICINE ONLINE
卷 27, 期 5, 页码 486-496出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.rbmo.2013.05.014
关键词
biomarker validation; endometrium; genomics; proteomics; receptivity; uterine fluid
Successful implantation of an embryo into the uterus requires synchrony between the blastocyst and the endometrium. Endometrial preparedness, or receptivity, occurs only for a very short time during the mid-secretory phase of the menstrual cycle in fertile women. Failure to achieve receptivity results in infertility and is a rate-limiting step for IVF success. Frozen embryo transfer in non-stimulation cycles is already improving live birth rates. However, an important tool that is missing in the armoury of reproductive specialists is a means to rapidly assess endometrial receptivity, either during initial assessment or immediately prior to embryo transfer. The development of a wealth of omics technologies now opens the way for identifying potential receptivity markers, although validation of these is still a major issue. This review assesses the current state of the field and the requirements to proceed to a valid clinical test. Crown Copyright (C) 2013, Published by Elsevier Company on behalf of Reproductive Healthcare Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据