期刊
REPRODUCTIVE BIOMEDICINE ONLINE
卷 26, 期 1, 页码 62-67出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.rbmo.2012.10.001
关键词
embryo quality; follicular fluid; ICSI; sRAGE
资金
- Sao Paulo Research Foundation (FAPESP) [2007/58467-0]
- National Council for Scientific and Technological Development of Brazil (CNPq) [579224/2008-2]
The developmental potential of human embryos has important implications in assisted reproduction and depends, among other factors, on oocyte competency. The receptor for advanced glycation end products (RAGE) is a member of the superfamily of immunoglobulin cell-surface molecules that are constitutively expressed during embryonic development. RAGE is down-regulated in homeostasis in adult life. This study measured the concentration of soluble RAGE (sRAGE) in follicular fluid obtained from the leading follicle after ovarian stimulation of 54 women undergoing intracytoplasmic sperm injection. Corresponding embryos and sRAGE concentrations in follicular fluid were evaluated and correlations were investigated by multi-adjusted regression analysis. High intrafollicular sRAGE concentrations predicted poor-quality embryos (n = 45, OR = 0.986; P = 0.026), adjusted for patient age, body mass index and oocyte quality, showing an inverse association between intrafollicular sRAGE concentrations and embryo development. RBMOnline (C) 2012, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.
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