Lack of association of WNT5A mutations with Mullerian duct abnormalities

The aim of this study was to determine if mutations in WNT5A contribute to the aetiology of Mullerian duct abnormalities (MDA) in 189 Chinese women. Three novel single-nucleotide polymorphisms (SNP; IVS2 - 115G > A, IVS4 + 66T > A, IVS4 + 102G > T) in introns 2 and 4 as well as one known SNP (rs62620048) in exon 6 were detected, but no causal mutations were observed. The results suggested that mutations in WNT5A may be not responsible for MDA in Chinese women. RBMOnline (C) 2012, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.