期刊
REPRODUCTIVE BIOMEDICINE ONLINE
卷 25, 期 5, 页码 500-503出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.rbmo.2012.07.013
关键词
cardiovascular disease; inflammation; polycystic ovary syndrome; weight loss
资金
- Australian Federation of University Women Postdoctoral Grants
- National Health and Medical Research Council
- University of Adelaide Faculty of Health Sciences
- Colin Matthews Research Grants for Clinically Based Research
- Commonwealth Scientific and Industrial Research Organisation Human Nutrition
Polycystic ovary syndrome (PCOS) is associated with increased cardiovascular disease risk. The effect of weight loss on the vascular inflammatory markers plasminogen activator inhibitor-1 (PAI-1), asymmetric dimethylarginine (ADMA), soluble vascular cell adhesion molecule-1 (sVCAM-1) and intracellular adhesion molecule-1 (sICAM-1) is unknown. Overweight women with (n = 14) and without (n = 13) PCOS of comparable age and body mass index undertook an 8-week weight-loss programme. Women with PCOS had elevated PAI-1, sVCAM-1 and sICAM-1 before and after weight loss compared with the controls. For all women, sVCAM-1 (P = 0.026) and sICAM-1 (P = 0.04) decreased with weight loss. Women with PCOS have elevated inflammatory markers, which are partially reduced by weight loss. (C) 2012, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.
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