期刊
REPRODUCTIVE BIOMEDICINE ONLINE
卷 20, 期 6, 页码 848-856出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.rbmo.2010.03.005
关键词
donor oocyte; embryo quality; in-vitro fertilization; live birth rate; paternal age; total reproductive potential
This study assessed the influence of the age of the male partner on the outcome of oocyte donation cycles. A total of 408 couples participating in 519 consecutive anonymous oocyte donation cycles were examined. Main outcome measures were fertilization rate, embryo quality, clinical pregnancy, implantation, miscarriage and live birth rates, as well as the total reproductive potential, which estimates the outcome from fresh and cryopreserved thawed embryo transfers. A total of 241 cycles resulted in clinical pregnancy (48.5% of transfers). The mean embryo score for transferred embryos (ESTE) was higher in cycles resulting in pregnancy (P = 0.003). Semen volume (P < 0.001), sperm motility (P < 0.001) and fertilization rate (P = 0.04) decreased significantly with advanced male age, which did not correlate with mean ESTE or implantation rate. Fertilization rate was the only predictor of ESTE (B = 16.066, P = 0.012), whereas inseminated/retrieved egg ratio was the only predictor of implantation rate (B = 0.555, P = 0.039). Pregnancy was only predicted by ESTE (Exp(B) = 1.023, P < 0.001), which also was the only predictor of live birth (Exp(B) = 1.017, P = 0.009). There was no predictor of miscarriage (47 cycles, 9.1%) identified. Although semen volume, sperm motility and fertilization rate decreased with advanced male age, embryo quality, clinical pregnancy, implantation, miscarriage and live birth rates were not affected. (C) 2010, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.
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