期刊
REPRODUCTIVE BIOMEDICINE ONLINE
卷 21, 期 3, 页码 349-359出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.rbmo.2010.04.012
关键词
endometrium; hormone treatment; implantation; integrins; osteopontin
资金
- Fondo de Investigaciones Sanitarias [PI02/0036]
The osteopontin: alpha v beta 3 integrin complex has been proposed as a means of distinguishing receptive from non-receptive endometrium in clinical practice, thus offering new directions for the development of contraceptive approaches targeted to the endometrium as well as a better understanding of occult causes of infertility in women. Histological dating and immunohistochemical study were performed in control and study cycles in seven groups of women including 10 subjects per group and who received clomiphene citrate, ovarian stimulation for IVF, oral contraception, dehydrogesterone for endometrial luteal phase defect, two different regimens of hormone replacement therapy, or no treatment. Ten healthy fertile women served as a general control group. Osteopontin and alpha v beta 3 integrin expression in the human endometrium was closely related to endometrial maturation and this was irrespective of the endometrium being in-phase or out-of-phase and the hormonal treatment (or no treatment) received. In conclusion, immunohistochemical assessment of the endometrium indicates that the use of osteopontin and alpha v beta 3 integrin or the osteopontin: alpha v beta 3 integrin complex as targets for the development of contraceptive approaches or the understanding of the pathogenesis of female infertility offer little benefit compared with simple histological dating. (C) 2010, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据