期刊
REPRODUCTIVE BIOMEDICINE ONLINE
卷 20, 期 5, 页码 681-688出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.rbmo.2010.01.018
关键词
case-control; dioxin-like compounds; DR-CALUX bioassay; endometriosis; environment
资金
- Endometriosis Association
- FWO (Fonds voor Wetenschappelijk Onderzoek/Foundation for Scientific Research, Vlaanderen)
- Onderzoeksraad KU Leuven (Leuven University Research Foundation)
Although endometriosis is thought to be an environmental disorder initiated by dioxin exposure, this association is controversial. This study was performed to test the hypothesis that endometriosis occurs more often in women exposed to higher concentrations of dioxin-like compounds (DLC) than in those women exposed to lower concentrations. Plasma samples collected prior to laparoscopic surgery from 96 women with endometriosis and 106 control patients with a normal pelvis were measured for DLC concentrations using the dioxin-responsive chemical-activated luciferase expression bioassay. The results showed that concentration (mean +/- SD) of DLC was marginally higher in patients with endometriosis (22.3 +/- 9.3 pg CALUX-TEQ/g lipid) than in controls (20.5 +/- 10.8 pg). After categorization of patients in a group with 'low' plasma concentrations (<25th centile) and a group with 'high' plasma concentrations (>75th centile) of DLC, the age-adjusted odds ratio to have endometriosis was 2.44 (95% CI 1.04-5.70; P = 0.04) for women with high concentrations of DLC and it increased to 3.01 (95% Cl 1.06-9.04; P = 0.03) when only women with moderate severe endometriosis were considered. In conclusion, women exposed to higher plasma concentrations of DLC were at higher risk of having endometriosis than women exposed to lower concentrations of DLC within normal environmental concentrations. (C) 2010, Reproductive Health Care Ltd. Published by Elsevier Ltd. All rights reserved.
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