期刊
REPRODUCTIVE BIOMEDICINE ONLINE
卷 18, 期 -, 页码 17-27出版社
ELSEVIER SCI LTD
DOI: 10.1016/S1472-6483(10)60111-3
关键词
amniotic fluid; fetal cells; regenerative medicine; stem cells
资金
- Great Ormond Street Hospital Childrens Charity [V1230] Funding Source: researchfish
Human amniotic fluid cells have been used as a diagnostic tool for the prenatal diagnosis of fetal genetic anomalies for more than 50 years. Evidence provided in the fast 5 years, however, suggests that. they can also harbour a therapeutic potential for human diseases, as different populations of fetal-derived stem cells have been isolated from amniotic fluid. Mesenchymal stern cells were the first to be described, which possess the higher proliferation and differentiation plasticity of adult mesenchymal stem cells and are able to differentiate towards mesodermal lineages. Amniotic fluid stern cells have more recently been isolated. They represent a novel class of pluripotent stem cells with intermediate characteristics between embryonic and adult stem cells. as they are able to differentiate into lineages representative of all three germ layers but do not form tumours when injected in vivo. These characteristics, together with the absence of ethical issues concerning their employment. suggest that stem cells present in the amniotic fluid might be promising candidates for tissue engineering and stem cell therapy of several human disorders.
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