期刊
REPRODUCTIVE BIOMEDICINE ONLINE
卷 16, 期 1, 页码 23-25出版社
ELSEVIER SCI LTD
DOI: 10.1016/S1472-6483(10)60553-6
关键词
adult onset disease; endocrine disruption; epigenetics; germ line programming; transgenerational
资金
- NIEHS NIH HHS [R01 ES012974] Funding Source: Medline
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [R01ES012974] Funding Source: NIH RePORTER
Epigenetic programming of the germ line occurs during embryonic development in a sex-specific manner. The male germ line becomes imprinted following sex determination. Environmental influences can alter this epigenetic programming and affect not only the developing offspring, but also potentially subsequent generations. Exposure to an endocrine disruptor (i.e. vinclozolin) during embryonic gonadal sex determination can alter the male germ-line epigenetics (e.g. DNA methylation). The epigenetic mechanism involves the alteration of DNA methylation in the germ line that appears to transmit transgenerational adult onset disease, including spermatogenic defects, prostate disease, kidney disease and cancer.
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