期刊
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
卷 9, 期 -, 页码 -出版社
BIOMED CENTRAL LTD
DOI: 10.1186/1477-7827-9-7
关键词
-
资金
- Ministry of Education of China [20090001110090]
- National Natural Science Funds for Distinguished Young Scholar [30825038]
- Ministry of Science & Technology of China [2007BA104B00]
Background: Recent research show that polycystic ovary syndrome (PCOS) may have an association with low-grade chronic inflammation, IL-18 is considered as a strong risk marker of inflammation. Methods: To investigate serum IL-18 concentrations in PCOS patients and focus on its relationship between obesity and insulin resistance (IR). Sixty consecutive women with PCOS and thirty controls were recruited. Serum level of IL-18 and fasting blood glucose, fasting insulin, follicle-stimulating hormone (FSH), luteinizing hormone (LH) and testosterone (T) were measured. Results: Serum levels of IL-18 was significantly higher in the PCOS group than in the control group. Serum level of IL-18 was higher in the PCOS group with IR than in the PCOS group without IR. Serum level of IL-18 was higher in obese PCOS patients than in lean PCOS patients. Serum level of IL-18 was higher in lean PCOS patients than in the lean control group. Serum level of IL-18 in the PCOS group was positively related to BMI, IR index and T. Conclusion: IL-18 level was increased in PCOS patients, and correlated with insulin resistance, obesity and hyperandrogenism.
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