期刊
REPRODUCTION IN DOMESTIC ANIMALS
卷 47, 期 -, 页码 261-265出版社
WILEY-BLACKWELL
DOI: 10.1111/rda.12010
关键词
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资金
- National Center for Research Resources of the National Institutes of Health (NIH) [R01 RR026064]
- Office of Research Infrastructure Programs/Office of the Director [R01 OD 010948]
Contents Innovations are emerging from the growing field of fertility preservation for humans and laboratory animals that are relevant to protecting and propagating valuable domestic and wild carnivores. These extend beyond the classical approaches associated with sperm, oocyte and embryo freezing to include gonadal tissue preservation combined with in vitro culture or xenografting, all of which have potential for rescuing vast amounts of unused and wasted germplasm. Here, we review approaches under development and predicted to have applied value within the next decade, including the following: (i) direct use of early-stage gametes for in vitro fertilization; (ii) generation of more mature gametes from gonadal tissue or stem cells; (iii) simplification, enhanced safety and efficacy of cryopreservation methods; and (iv) biostabilization of living cells and tissues at ambient temperatures. We believe that all of these fertility preservation strategies will offer knowledge and tools to better manage carnivores that serve as human companions, valuable biomedical models or require assistance to reverse endangerment.
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