期刊
REPRODUCTION
卷 147, 期 5, 页码 D1-D12出版社
BIOSCIENTIFICA LTD
DOI: 10.1530/REP-14-0080
关键词
-
资金
- NIH [R01HD-067759, R01HD077108]
- MRC
- Evelyn Trust, Cambridge
- Hospitals National Institute for Health Research Biomedical Research Centre
- Cambridge Centre for Trophoblast Research
- British Heart Foundation Intermediate Basic Science Research Fellowship [FS/12/37/29516]
- Fannie and John Hertz Foundation
- U.S. National Science Foundation
- Davidson Institute for Talent Development
- British Heart Foundation [FS/12/37/29516] Funding Source: researchfish
It is imperative to unveil the full range of differentiated cell types into which human pluripotent stem cells (hPSCs) can develop. The need is twofold: it will delimit the therapeutic utility of these stem cells and is necessary to place their position accurately in the developmental hierarchy of lineage potential. Accumulated evidence suggested that hPSC could develop in vitro into an extraembryonic lineage (trophoblast (TB)) that is typically inaccessible to pluripotent embryonic cells during embryogenesis. However, whether these differentiated cells are truly authentic TB has been challenged. In this debate, we present a case for and a case against TB differentiation from hPSCs. By analogy to other differentiation systems, our debate is broadly applicable, as it articulates higher and more challenging standards for judging whether a given cell type has been genuinely produced from hPSC differentiation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据