期刊
REPRODUCTION
卷 142, 期 5, 页码 633-646出版社
BIOSCIENTIFICA LTD
DOI: 10.1530/REP-11-0136
关键词
-
资金
- National Institute on Environmental Health Sciences (NIEHS) [R01ES012893, R01ES019178]
- Billie A Field Fellowship in Reproductive Biology
Endocrine-disrupting chemicals (EDCs) are exogenous agents with the ability to interfere with processes regulated by endogenous hormones. One such process is female reproductive function. The major reproductive organ in the female is the ovary. Disruptions in ovarian processes by EDCs can lead to adverse outcomes such as anovulation, infertility, estrogen deficiency, and premature ovarian failure among others. This review summarizes the effects of EDCs on ovarian function by describing how they interfere with hormone signaling via two mechanisms: altering the availability of ovarian hormones, and altering binding and activity of the hormone at the receptor level. Among the chemicals covered are pesticides (e.g. dichlorodiphenyltrichloroethane and methoxychlor), plasticizers (e. g. bisphenol A and phthalates), dioxins, polychlorinated biphenyls, and polycyclic aromatic hydrocarbons (e. g. benzo[ a] pyrene). Reproduction (2011) 142 633-646
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据