期刊
REJUVENATION RESEARCH
卷 16, 期 1, 页码 74-77出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/rej.2013.1414
关键词
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Methylation of DNA is intimately involved in control of mammalian/vertebrate gene expression as part of a complex epigenetic regulatory system. We hypothesize that DNA methylation at cytosine-phosphate-guanine sites (CpGs), the DNA methylome, evolved to increase stability of the differentiated state in somatic vertebrate cells, especially post-mitotic cells, which may have helped to increase longevity. Therefore, the DNA methylome may play a key role in human aging and be an ideal source of biomarkers aging. A new model that links the methylome to chronological age has been reported by Hannum et al.(1) that accurately predicts age and rate of aging from the DNA methylation state of 71 markers in human blood samples. This model may make possible the development of new anti-aging therapeutics as well as more accurately assess the impact of anti-aging regimens, such as caloric restriction and drugs such as rapamycin. Furthermore, the model reveals information loss with increased age consistent with noise/unstable diffentiation-based models of aging. The model may eventually lead to experiments to differentiate the contributions of biomolecular damage and noise/incomplete structural replication during aging.
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