期刊
REGULATORY TOXICOLOGY AND PHARMACOLOGY
卷 65, 期 3, 页码 311-315出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.yrtph.2013.01.004
关键词
Bottom-up approach; Carcinogenic risk assessment; Unit risk; q(1)*; Upper 95% confidence bound risk estimate; DNA adducts; Formaldehyde
资金
- Research Foundation for Health and Environmental Effects, Washington DC
We propose a novel bottom-up approach to the bounding of low-dose human cancer risks from chemical exposures that does not rely at all upon high-dose data for human or animal cancers. This approach can thus be used to provide an independent reality check on low-dose risk estimates derived with dose-response models that are fit to high-dose cancer data. The approach (1) is consistent with the additivity to background concept, (2) yields central and upper-bound risk estimates that are linear at all doses, and (3) requires only information regarding background risk, background (endogenous) exposure, and the additional exogenous exposure of interest in order to be implemented. After describing the details of this bottom-up approach, we illustrate its application using formaldehyde as an example. Results indicate that recent top-down risk extrapolations from occupational cohort mortality data for workers exposed to formaldehyde are overly conservative by substantial margins. (C) 2013 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据