期刊
REGULATORY TOXICOLOGY AND PHARMACOLOGY
卷 51, 期 2, 页码 S43-S50出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.yrtph.2007.12.002
关键词
naphthalene; cancer; carcinogenicity; mutagenicity; mode of action; mechanism of action; genotoxicity; metabolism; 1,2-naphthoquinone; DNA adducts; stable adducts; depurinating adducts; biomarkers
资金
- NIEHS NIH HHS [R01 ES007462, R01 ES007462-12] Funding Source: Medline
This report provides a summary of deliberations conducted under the charge for members of Module D participating in the Naphthalene State-of-the-Science Symposium (NS3), Monterey, CA, October 9-12, 2006. The charge directed the panel to ascertain to the best of its ability a consensus judgment of the state-of-the-science concerning the potential for a genotoxic mode of action for naphthalene and its metabolites, with implications for low-dose extrapolations of cancer risk estimates for exposed populations. Where scientific uncertainties remained, the panel was asked to identify which scientific uncertainties (if any) could be resolved through targeted, timely, cost-effective research. The report provides a brief summary of naphthalene genotoxicity; identifies those areas where there is a general scientific consensus regarding the effects of naphthalene; identifies areas of uncertainty regarding the effects of naphthalene; and key questions that currently limit our ability to assess the genotoxic risks of naphthalene. The report also outlines a set of six studies that could resolve some of these key uncertainties. (C) 2007 Elsevier Inc. All rights reserved.
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