期刊
REGULATORY PEPTIDES
卷 186, 期 -, 页码 57-61出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.regpep.2013.07.007
关键词
Bursal peptide (BP); Reversed-phase HPLC; Immunomodulatory function; Immunization experiment
资金
- National Agriculture Special Research Project for Non-Profit Trades, Ministry of Agriculture [200803020]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
The bursa of Fabricius (BF) is the acknowledged central humoral immune organ unique to birds which plays important roles in B cell development and antibody production. Little information on immunomodulatory functions of BF is reported, except for several reported active bursal-derived peptides. Three peptides were identified and characterized from BF through RP-HPLC and MADIL-TOF methods. They are named as bursal peptide (BP)-I, BP-II, BP-Ill. These peptides promoted CFU pre-B formation and decreased PU.1 expression. The different immunomodulatory activities of these three bursal peptides on antibody and cytokine productions were verified by the immunization comparative experiment. The results showed the three bursal peptides enhanced AIV-specific antibody and cytokine production, T-cell immunophenotyping at reachable concentrations. These results indicate the important orientations for the comprehensive understanding of the humoral central immune system, and provide a novel insight on new experimental reagents for immuno-adjuvant or immunopharmacological. (C) 2013 Elsevier B.V. All rights reserved.
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