期刊
REGULATORY PEPTIDES
卷 149, 期 1-3, 页码 11-14出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.regpep.2007.08.027
关键词
blood-brain barrier; central nervous system; gut-brain interactions; leptin; insulin; ghrelin
资金
- NIA NIH HHS [R01 AG029839, R01 AG029839-01A1] Funding Source: Medline
- NINDS NIH HHS [R01 NS050547, R01 NS050547-03] Funding Source: Medline
The BBB prevents the unrestricted exchange of substances between the central nervous system (CNS) and the blood. The blood-brain barrier (BBB) also conveys information between the CNS and the gastrointestinal (GI) tract through several mechanisms. Here, we review three of those mechanisms. First, the BBB selectively transports some peptides and regulatory proteins in the blood-to-brain or the brain-to-blood direction. The ability of GI hormones to affect functions of the BBB, as illustrated by the ability of insulin to alter the BBB transport of amino acids and drugs, represents a second mechanism. A third mechanism is the ability of GI hormones to affect the secretion by the BBB of substances that themselves affect feeding and appetite, such as nitric oxide and cytokines. By these and other mechanisms, the BBB regulates communications between the CNS and GI tract. Published by Elsevier B.V.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据