期刊
REGULATORY PEPTIDES
卷 149, 期 1-3, 页码 70-78出版社
ELSEVIER
DOI: 10.1016/j.regpep.2007.10.008
关键词
macronutrients; fibre; intestine; peptide release; satiety; humans
资金
- Academy of Finland [110525, 118191, 118281]
- Technology Development Centre of Finland (Tekes)
- Nordic Innovation Centre
- Novo Nordisk Foundation
- Jalmari and Rauha Ahokas Foundation
- Academy of Finland (AKA) [118191, 118281, 110525, 118281, 110525, 118191] Funding Source: Academy of Finland (AKA)
Short-term regulation of food intake controls what, when and how much we eat within a single day or a meal. This regulation results from an integrated response to neural and humoral signals that originate from the brain, gastrointestinal (GI) tract and adipose tissue. In the GI tract, multiple sites including the stomach, duodenum, distal small intestine, colon, and pancreas are involved in this process. Ingested food evokes satiety by mechanical stimulation and by release of peptides in the GI tract. The intestine in particular plays a key role in satiety through various peptides secreted in response to food. Many of the intestinal peptides inhibit also gastric emptying thus enhancing gastric mechanoreceptor stimulation. In this review, the current knowledge about the effects of different macronutrients and fibre on the release of GI satiety-related peptides in humans is discussed. (C) 2008 Elsevier B.V. All rights reserved.
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