期刊
REGENERATIVE MEDICINE
卷 6, 期 6, 页码 701-706出版社
FUTURE MEDICINE LTD
DOI: 10.2217/RME.11.89
关键词
composite organ transplantation; good manufacturing practices; hand transplantation; Pittsburgh Protocol; vertebral bodies; vertebral bone marrow
资金
- Armed Forces Institute for Regenerative Medicine
- Orthopedic Trauma Research Program
- University of Pittsburgh Medical Center
Aims: Vertebral bone marrow is a rich and easily accessible source of hematopoietic and mesenchymal stem cells that has been used to promote chimerism and transplantation tolerance in connection with cadaveric organ transplantation. The purpose of this study is to provide a detailed account of the procedure used to prepare the first five vertebral bone marrow products for infusion in conjunction with the first hand/hand-forelimb transplants performed at the University of Pittsburgh (PA, USA). Materials & methods: The cell separation and release testing were performed at the University of Pittsburgh Cancer Institute's Hematopoietic Stem Cell Laboratory, a Good Manufacturing Practice-compliant facility accredited for clinical cell processing by the Foundation for Accreditation of Cellular Therapy (FACT) and for clinical flow cytometry by the College of American Pathologists (CAP).
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