期刊
REGENERATIVE MEDICINE
卷 4, 期 5, 页码 697-707出版社
FUTURE MEDICINE LTD
DOI: 10.2217/RME.09.45
关键词
dental pulp stem cells; mesenchymal stem cells; stem cells from apical papilla; stem cells from human exfoliated deciduous teeth; tissue engineering; tissue regeneration
资金
- NIDCR NIH HHS [R01 DE019156-05, R01 DE019156-01, R01 DE019156] Funding Source: Medline
Dental pulp tissue is vulnerable to infection. Entire pulp amputation followed by pulp-space disinfection and filling with an artificial rubber-like material is employed to treat the infection - commonly known as root-canal therapy. Regeneration of pulp tissue has been difficult as the tissue is encased in dentin without collateral blood supply except from the root apical end. However, with the advent of the concept of modern tissue engineering and the discovery of dental stem cells, regeneration of pulp and dentin has been tested. This article will review the early attempts to regenerate pulp tissue and the current endeavor of pulp and dentin tissue engineering, and regeneration. The prospective outcome of the current advancement in this line of research will be discussed.
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