期刊
REDOX REPORT
卷 16, 期 3, 页码 129-133出版社
TAYLOR & FRANCIS LTD
DOI: 10.1179/1351000211Y.0000000002
关键词
NF-kappa B; Nrf2; Oxidative stress; Pirin; Superoxide dismutase
资金
- Ministry of Science and Higher Education [6P04A 00620]
- Institute of Nuclear Chemistry and Technology
- Institute of Agricultural Medicine
Iron binding protein pirin was isolated as an interactor of the NFIX transcription factor but it can also form complexes with Bcl3 and NF-kappa B1(p50). Alterations of pirin expression were observed in various tumors and after exposure to pro-carcinogenic oxidative stressors. The aim of the present work was to study the level of pirin transcription in an in vivo model of oxidative stress, namely, in Sod1-deficient mice. We have found that Sod1(-/-) mice have a significantly elevated level of Pir mRNA in the spleen and kidney but not in the liver, heart, or/and brain. We have also shown that similarly to its human ortholog, the mouse Pir gene transcription level varies significantly between organs. The highest expression was found in the liver and the lowest in the spleen and kidney. Based on literature data, we propose the involvement of Nrf2, AP-1, and NF-kappa B transcription factors in Pir up-regulation in Sod1(-/-) mice.
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