期刊
REACTIVE & FUNCTIONAL POLYMERS
卷 133, 期 -, 页码 21-28出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.reactfunctpolym.2018.09.015
关键词
Hydrogel; Poly(aspartic acid); Enzymatic degradation; Trypsin; Drug release
资金
- National Research, Development and Innovation Office (NKFIH) [FK 125074]
- Higher Education Excellence Program of the Ministry of Human Capacities of Biotechnology research area of Budapest University of Technology and Economics (BME FIKP-BIO)
- Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences
- Ministry of Human Capacities [UNKP-17-4-III]
The synthesis of a chemically cross-linked polymer hydrogel consisting exclusively of amino acids is described in this paper. A natural amino acid, aspartic acid was polymerized to polysuccinimide which was cross-linked by a tetrapeptide sequence designed for proteolytic degradation, and then the corresponding poly(aspartic acid) hydrogel was obtained by alkaline hydrolysis. The hydrogel dissolved in the presence of trypsin. According to in vitro cellular assays, the degradation products of the hydrogel cross-linked with the peptide were non-cytotoxic and non-cytostatic. The sustained release of an encapsulated macromolecular model drug, FITC-dextran, was triggered by the degradation of the hydrogel induced by trypsin. These results suggest the potential application of the trypsin-responsive hydrogel for drug delivery in the small intestine.
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