期刊
REACTIVE & FUNCTIONAL POLYMERS
卷 83, 期 -, 页码 54-61出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.reactfunctpolym.2014.07.008
关键词
Antimicrobial peptides; Biodegradable polyesters; Biodegradable poly(ester-carbonate)s; Controlled release; Citropin
资金
- Ministry of Science and Higher Education in Poland [OR 0000 25 12]
The effective synthesis of citropin-polymer conjugates was described in this paper. The obtained biodegradable polymeric matrices and polymeric conjugates were characterized using H-1 or C-13 NMR and Fourier transform infrared spectroscopies, gel permeation chromatography and scanning electron microscopy. Toxicity of polymers was evaluated with bacterial luminescence test and two protozoan assays. The in vitro release study of citropin from the obtained conjugates was investigated. The preliminary results of antimicrobial activity of the obtained macromolecular conjugates against Bacillus anthracis, Enterococcus hirae and Staphylococcus aureus were also discussed. The peptide had a high level of antimicrobial activity during 3-5 weeks of the degradation process. The development of biodegradable citropin systems should be of a great interest in the delivery systems of antimicrobial agents. (C) 2014 Published by Elsevier B.V.
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