期刊
REACTIVE & FUNCTIONAL POLYMERS
卷 82, 期 -, 页码 81-88出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.reactfunctpolym.2014.06.003
关键词
Conducting hydrogels; Modification; Controlled release; Carboxymethyl chitosan; Aniline oligomers
资金
- National Natural Science Foundation of China [21304073]
- Fundamental Research Funds for the Central Universities [xjj2013029]
- Scientific Research Foundation for the Returned Overseas Chinese Scholars
Cytocompatible electrically conducting hydrogels based on amphoteric carboxymethyl chitosan (CMCS) and aniline oligomers with bioactive molecule delivery properties were presented. A series of conductive CMCS hydrogels with different aniline pentamer (AP) content were synthesized by a one-pot reaction with the combination of grafting and crosslinking reaction via glutaraldehyde. The conductivities of the swollen hydrogels are between 1.14 x 10(-4) and 4.23 x 10(-4) S/cm by tuning the AP content. Swelling ratio was controlled by the AP content and crosslinking degree of the hydrogels. The hydrogels showed absorption capacity of diclofenac sodium (DCS) as a model molecule and released DCS in a controlled manner. Morphologies and mechanical properties of the hydrogels were characterized by SEM and rheometer, respectively. The biocompatibility of the hydrogels was confirmed by C2C12 myoblast cells using Live/Dead assay and Alamar blue assay. These conducting hydrogels with controlled release capacity as bioactive scaffolds have potential application for tissue regeneration. (C) 2014 Elsevier Ltd. All rights reserved.
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