期刊
REACTIVE & FUNCTIONAL POLYMERS
卷 70, 期 5, 页码 301-305出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.reactfunctpolym.2010.02.003
关键词
Chitosan; PLA; Graft copolymer; Self-catalysis; Gene complex
资金
- National Natural Science Foundation of China (NSFC) [50573073]
- Shanghai International Collaboration Foundation [08410701800]
- NSFC-CIHR Foundation [30811120440]
The graft copolymer of chitosan-g-polylactide (CS-g-PLA) was synthesized successfully through ring-opening polymerization of lactide onto phthaloyl-protected chitosan by a self-catalysis strategy. After graft copolymerization, the phthaloyl groups were deprotected to regenerate free amino groups in the CS-g-PLA. FT-IR and NMR were used to characterize the graft copolymers both before and after the deprotection. We observed that degradation of the grafted PLA chains occurred in the alkaline deprotection process, and this process was optimized. Moreover, the CS-g-PLA containing the amino-polysaccharide backbone was formed into a polyelectrolyte complex with DNA. The resultant CS-g-PLA/DNA complexes were determined to be about 60 nm, with a positive charge above an N/P of 4/1. (c) 2010 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据