期刊
RAPID COMMUNICATIONS IN MASS SPECTROMETRY
卷 26, 期 23, 页码 2683-2689出版社
WILEY-BLACKWELL
DOI: 10.1002/rcm.6392
关键词
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资金
- National Natural Science Foundation of China [21005075, 21175127]
- Scientific and Technological Development Program of Jilin Province [20090739, 20101501]
- Jilin Province Science and Technology Department [YYZX201131]
RATIONALE 20(S)-ginsenoside Rg3 is an active component of Panax ginseng. It is known that 20(S)-ginsenoside Rg3 has a protective effect against hyperglycemia, obesity and diabetes in vivo, but the precise mechanisms of these actions have not yet been entirely elucidated. METHODS A urinary metabonomics method based on rapid-resolution liquid chromatography/mass spectrometry (RRLC/MS) was developed to investigate the effect of 20(S)-ginsenoside Rg3 on type 2 diabetic rats. RESULTS With multivariate statistical analysis, a clear separation between type 2 diabetic rats and those treated with 20(S)-ginsenoside Rg3 was achieved. Six potential biomarkers were found and identified. CONCLUSIONS This work shows that the mechanism of the effect of 20(S)-ginsenoside Rg3 on type 2 diabetes may be involved with the regulation of nucleic acid metabolism, energy metabolism and gut flora metabolism. Copyright (C) 2012 John Wiley & Sons, Ltd.
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