期刊
RAPID COMMUNICATIONS IN MASS SPECTROMETRY
卷 25, 期 21, 页码 3223-3234出版社
WILEY-BLACKWELL
DOI: 10.1002/rcm.5218
关键词
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资金
- National Basic Research Priorities Program [2007CB914100]
- National Science Foundation of China [21027002]
- Shanghai Leading Academic Discipline Project [B109]
In this work, graphene (G) and graphene oxide (GO) were utilized to enrich and ionize long-chain fatty acids. All together five long-chain fatty acids were selected as models here, n-dodecanoic acid (C12), n-tetradecanoic acid (C14), n-hexadecanoic acid (C16), n-octadecanoic acid (C18), and n-eicosanoic acid (C20). Due to the large surface area and strong interaction force of G or GO, all the five long-chain fatty models were effectively enriched by G or GO. On the other hand, the excellent electronic, thermal, and mechanical properties enable G and GO to be prefect energy receptacles for laser radiation, which make the ionization steps more effective. Eventually, the promoted G and GO methodology can sensitively detect the five long-chain fatty acid models from real biological samples even at low concentrations. Meanwhile, by adopting our promoted methodology, the detection of long-chain fatty acids by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) was demonstrated to be simple, sensitive, fast, cost effective and high throughput, which is meaningful as to practical usage. Copyright (C) 2011 John Wiley & Sons, Ltd.
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